Stoner contended Dovizioso for the lead on lap two, with the Italian holding the top spot for several corners until pole position starter Stoner took over the lead from his team mate. Meanwhile, Simoncelli, who started from second position, positively hunted down the Repsol Hondas from his third position in the field until he ran wide on the 4th lap and lost the position back to Lorenzo.

With rain steadily falling and conditions worsening, Lorenzo highsided out of third position on lap 8, making the Silverstone race the first he did not finish since 2009.

This put the 25 year old Simoncelli in third position, but not content to settle for his first podium position to be a third, he pushed to pass Dovizioso until he lost the front under braking on lap ten.

Stoner stretched a gap of 15 seconds ahead of field, eventually lapping Héctor Barberá (Mapfre Aspar) and Randy de Puniet (Pramac Racing) with three and a half laps left in the race, the two of whom finished 11th and 12th respectively.

The surprise of the weekend came with Colin Edwards piloting his Monster Yamaha Tech 3 bike to a podium finish. The 'Texas Tornado', who broke his collarbone last week in practice at Catalunya, started from eighth on the grid to ride a consistent race. Edwards benefited from the setbacks of Lorenzo and Simoncelli, thus earning his first podium of the season.

Nicky Hayden (Ducati Team), who set the fastest lap of the race, followed fellow American Edwards across the line in fourth.

Álvaro Bautista (Rizla Suzuki) in fifth. Valentino Rossi (Ducati Team) finished sixth, in front of Czech rider Karel Abraham (Cardion AB Motoracing).

Toni Elias made a good launch off the start, putting his LCR Honda into eighth on the first lap from his 14th grid position. The Moto2 Champion crossed the line in eighth position, with Hiroshi Aoyama (San Carlo Honda Gresini) in ninth and Loris Capirossi (Pramac Racing) in tenth.

Ben Spies (Yamaha Factory Racing) crashed out of the race on lap 14.